If the system works as advertised, then there is no earthly reason why alphanumeric flights (and scheduled freight flights) shouldn't be treated exactly the same as any other.
After all, we're simply talking about tieing a callsign to an airport (or pair of airports) based on deducing that a flight is about to land there or has just taken off.
Incidentally, AirNav, how will you handle routes where network coverage only enables you to deduce the origin, but not the destination (or vice versa) ?